Zebrafish

Angiogenesis is a dynamic process by which new blood vessels form from pre-existing vasculature. This process begins with vasculogenesis, the de novo formation of vessels, which then go through further alteration and expansion through angiogenesis. Unlike most other tissues, vasculature exhibits a outstanding regenerative capacity, enabling it to grow and repair damaged tissues even in adult organisms.

Drug Discovery and Development is a complex, multi-phase process aimed at ensuring the safety and efficacy of new therapeutic compounds before they reach the market. This article provides a broad overview of the journey from initial discovery to market approval, with a special focus on the pivotal phase of Lead Optimization.

Chronic toxicity studies are specialized assays designed to evaluate the potential adverse health effects resulting from repeated or continuous exposure to a substance over an extended period. These studies aim to characterize the long-term impact of such exposure on biological systems. 

What is Cryopreservation? 

The European Chemicals Agency (ECHA) has introduced significant updates to the European Union (EU) CLP (Classification, Labelling, and Packaging) regulation, strengthening its framework for classifying and managing chemical hazards. These updates reflect scientific advancements and aim to protect human health and the environment from potential chemical risks. 

Before a drug can enter clinical trials in humans, it must undergo rigorous safety evaluations to assess its potential risks. This includes identifying not only mild adverse effects, such as headaches or dizziness, but also identifying or predicting life threatening toxicities that may arise.

The Organization for Economic Co-operation and Development (OECD) and the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) both play crucial roles in harmonizing global regulations on chemicals and drugs to ensure their safe use in humans and the environment.

In this blog post, we will explore what does in vitro means, what is in vitro testing and when are in vitro studies preferred to in vivo ones.

The unstoppable advance of medicine and the pharmaceutical industry has increased the volume of animal experimentation. Animal testing is crucial in Drug Discovery and Development, bridging in vitro research and human clinical trials.